[HTML][HTML] Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1
GW Humphrey, Y Wang, VR Russanova, T Hirai… - Journal of Biological …, 2001 - ASBMB
Human histone deacetylases I (HDAC1) and II (HDAC2) are homologous proteins (84‥
identity) that catalyze release of acetyl groups from modified N-terminal lysines of core
histones. Histone deacetylation is correlated with both transient and persistent states of
transcriptional inactivity (ie silencing) in many eukaryotes. In this study, we analyzed
complexes containing HDAC1 and HDAC2 to identify the proteins most stably associated
with these deacetylases. Complex cI (9.5 S) contained transcriptional corepressor …
identity) that catalyze release of acetyl groups from modified N-terminal lysines of core
histones. Histone deacetylation is correlated with both transient and persistent states of
transcriptional inactivity (ie silencing) in many eukaryotes. In this study, we analyzed
complexes containing HDAC1 and HDAC2 to identify the proteins most stably associated
with these deacetylases. Complex cI (9.5 S) contained transcriptional corepressor …