Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guerin vaccination
RM Brown, O Cruz, M Brennan… - The Journal of …, 2003 - academic.oup.com
RM Brown, O Cruz, M Brennan, ML Gennaro, L Schlesinger, YAW Skeiky, DF Hoft
The Journal of infectious diseases, 2003•academic.oup.comThe ability of 17 recombinant mycobacterial proteins, native antigen 85 complex,
lipoarabinomannan (LAM), and Mycobacterium tuberculosis lysate to detect antibody
responses induced by bacille Calmette-Guérin (BCG) vaccination and active tuberculosis
infection were studied in enzyme-linked immunosorbent assays. Only LAM-reactive serum
immunoglobulin G responses were significantly increased in both BCG-vaccinated patients
and patients with active tuberculosis (P<. 05), and oral BCG vaccination also induced …
lipoarabinomannan (LAM), and Mycobacterium tuberculosis lysate to detect antibody
responses induced by bacille Calmette-Guérin (BCG) vaccination and active tuberculosis
infection were studied in enzyme-linked immunosorbent assays. Only LAM-reactive serum
immunoglobulin G responses were significantly increased in both BCG-vaccinated patients
and patients with active tuberculosis (P<. 05), and oral BCG vaccination also induced …
Abstract
The ability of 17 recombinant mycobacterial proteins, native antigen 85 complex, lipoarabinomannan (LAM), and Mycobacterium tuberculosis lysate to detect antibody responses induced by bacille Calmette-Guérin (BCG) vaccination and active tuberculosis infection were studied in enzyme-linked immunosorbent assays. Only LAM-reactive serum immunoglobulin G responses were significantly increased in both BCG-vaccinated patients and patients with active tuberculosis (P<.05), and oral BCG vaccination also induced significant increases in LAM-reactive secretory immunoglobulin A (P<.05). LAM-reactive antibody assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer attenuated mycobacterial vaccines
Oxford University Press