[HTML][HTML] A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 …
JL Schmid-Burgk, D Chauhan, T Schmidt… - Journal of Biological …, 2016 - ASBMB
Inflammasomes are high molecular weight protein complexes that assemble in the cytosol
upon pathogen encounter. This results in caspase-1-dependent pro-inflammatory cytokine
maturation, as well as a special type of cell death, known as pyroptosis. The Nlrp3
inflammasome plays a pivotal role in pathogen defense, but at the same time, its activity has
also been implicated in many common sterile inflammatory conditions. To this effect, several
studies have identified Nlrp3 inflammasome engagement in a number of common human …
upon pathogen encounter. This results in caspase-1-dependent pro-inflammatory cytokine
maturation, as well as a special type of cell death, known as pyroptosis. The Nlrp3
inflammasome plays a pivotal role in pathogen defense, but at the same time, its activity has
also been implicated in many common sterile inflammatory conditions. To this effect, several
studies have identified Nlrp3 inflammasome engagement in a number of common human …