[HTML][HTML] Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein: implication for heme oxygenase-1 gene regulation
CH He, P Gong, B Hu, D Stewart, ME Choi… - Journal of biological …, 2001 - ASBMB
Nrf2 regulates expression of genes encoding enzymes with antioxidant (eg. heme
oxygenase-1 (HO-1)) or xenobiotic detoxification (eg. NAD (P) H: quinone oxidoreductase,
glutathione S-transferase) functions via the stress-or antioxidant-response elements
(StRE/ARE). Nrf2 heterodimerizes with small Maf proteins, but the role of such dimers in
gene induction is controversial, and other partners may exist. By using the yeast two-hybrid
assay, we identified activating transcription factor (ATF) 4 as a potential Nrf2-interacting …
oxygenase-1 (HO-1)) or xenobiotic detoxification (eg. NAD (P) H: quinone oxidoreductase,
glutathione S-transferase) functions via the stress-or antioxidant-response elements
(StRE/ARE). Nrf2 heterodimerizes with small Maf proteins, but the role of such dimers in
gene induction is controversial, and other partners may exist. By using the yeast two-hybrid
assay, we identified activating transcription factor (ATF) 4 as a potential Nrf2-interacting …