[HTML][HTML] Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR: LA-cp rat [S]
M Jacome-Sosa, C Vacca, R Mangat, A Diane… - Journal of lipid …, 2016 - ASBMB
Vaccenic acid (VA), the predominant ruminant-derived trans fat in the food chain,
ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA
could influence tissue endocannabinoids (ECs) by altering the availability of their
biosynthetic precursor, arachidonic acid (AA), in membrane phospholipids (PLs). JCR: LA-
cp rats were assigned to a control diet with or without VA (1% w/w), cis-9, trans-11
conjugated linoleic acid (CLA)(1% w/w) or VA+ CLA (1%+ 0.5% w/w) for 8 weeks. VA …
ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA
could influence tissue endocannabinoids (ECs) by altering the availability of their
biosynthetic precursor, arachidonic acid (AA), in membrane phospholipids (PLs). JCR: LA-
cp rats were assigned to a control diet with or without VA (1% w/w), cis-9, trans-11
conjugated linoleic acid (CLA)(1% w/w) or VA+ CLA (1%+ 0.5% w/w) for 8 weeks. VA …