A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor–refractory obsessive-compulsive disorder
CJ McDougle, CN Epperson, GH Pelton… - Archives of general …, 2000 - jamanetwork.com
Background To date, only 1 controlled study has found a drug (haloperidol) to be efficacious
in augmenting response in patients with obsessive-compulsive disorder (OCD) refractory to
serotonin reuptake inhibitor (SRI) monotherapy; patients with comorbid chronic tic disorders
showed a preferential response. This report describes the first controlled study of
risperidone addition in patients with OCD refractory to treatment with SRI alone. Methods
Seventy adult patients with a primaryDSM-IVdiagnosis of OCD received 12 weeks of …
in augmenting response in patients with obsessive-compulsive disorder (OCD) refractory to
serotonin reuptake inhibitor (SRI) monotherapy; patients with comorbid chronic tic disorders
showed a preferential response. This report describes the first controlled study of
risperidone addition in patients with OCD refractory to treatment with SRI alone. Methods
Seventy adult patients with a primaryDSM-IVdiagnosis of OCD received 12 weeks of …