DNA methylation pattern mapping is heavily studied in normal and diseased tissues. A
variety of methods have been established to interrogate the cytosine methylation patterns in
cells. Reduced representation of whole genome bisulfite sequencing was developed to
detect quantitative base pair resolution cytosine methylation patterns at GC-rich genomic
loci. This is accomplished by combining the use of a restriction enzyme followed by bisulfite
conversion. Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) increases …