The role of VE-cadherin in vascular morphogenesis and permeability control
E Dejana, D Vestweber - Progress in molecular biology and translational …, 2013 - Elsevier
VE-cadherin is an endothelial-specific cadherin that is essential for the formation and
regulation of endothelial cell junctions. The adhesive function and expression levels of VE-
cadherin at endothelial contacts are central determinants of the control of vascular
permeability and leukocyte recruitment into tissue. In addition to controlling junctional
integrity, VE-cadherin modulates a multitude of signaling processes that influence the
behavior of endothelial cells, such as proliferation, survival, migration, polarity, expression of …
regulation of endothelial cell junctions. The adhesive function and expression levels of VE-
cadherin at endothelial contacts are central determinants of the control of vascular
permeability and leukocyte recruitment into tissue. In addition to controlling junctional
integrity, VE-cadherin modulates a multitude of signaling processes that influence the
behavior of endothelial cells, such as proliferation, survival, migration, polarity, expression of …