LIPID COMPOSITION OF QUAKING MOUSE MYELIN: COMPARISON WITH NORMAL MOUSE MYELIN IN THE ADULT AND DURING DEVELOPMENT1
N Baumann, JM Bourre, C Jacque… - Journal of …, 1973 - Wiley Online Library
N Baumann, JM Bourre, C Jacque, ML Harpin
Journal of Neurochemistry, 1973•Wiley Online LibraryIn the 'Quaking'mouse, a deficiency in the long chain fatty acid content of galactolipids has
been shown to occur. Myelin in the mutant has been compared to myelin in adult and in 12‐
day‐old controls. We have shown that myelin is not only quantitatively reduced but also
qualitatively modified, with a higher protein and a lower galactolipid content. Cerebrosides
contain only a small amount of kerasin, lacking long chain nonhydroxylated fatty acids in
comparison to both controls; the relative percentage of phrenosin is increased. Although …
been shown to occur. Myelin in the mutant has been compared to myelin in adult and in 12‐
day‐old controls. We have shown that myelin is not only quantitatively reduced but also
qualitatively modified, with a higher protein and a lower galactolipid content. Cerebrosides
contain only a small amount of kerasin, lacking long chain nonhydroxylated fatty acids in
comparison to both controls; the relative percentage of phrenosin is increased. Although …
Abstract
In the ‘Quaking’ mouse, a deficiency in the long chain fatty acid content of galactolipids has been shown to occur.
Myelin in the mutant has been compared to myelin in adult and in 12‐day‐old controls. We have shown that myelin is not only quantitatively reduced but also qualitatively modified, with a higher protein and a lower galactolipid content. Cerebrosides contain only a small amount of kerasin, lacking long chain nonhydroxylated fatty acids in comparison to both controls; the relative percentage of phrenosin is increased.
Although many similarities exist between adult Quaking myelin and myelin at 12 days, differences have been shown to occur which may be in relation to a genetic block at an earlier stage of development.
Wiley Online Library