[HTML][HTML] The role of leukemia-derived B7-H1 (PD-L1) in tumor–T-cell interactions in humans
OBJECTIVE: Expression of the B7 homolog B7-H1 (PD1-Ligand) has been proposed to
enable tumor cells to evade immune surveillance. Recently, B7-H1 on murine leukemia cells
was reported to mediate resistance to cytolytic T-cell destruction. We here investigate the
expression and function of the B7 homolog B7-H1 in human leukemia. PATIENTS AND
METHODS: Leukemia cells from 30 patients and 9 human leukemia cell lines were
investigated for B7-H1 expression by flow cytometry. Functional relevance of B7-H1 for …
enable tumor cells to evade immune surveillance. Recently, B7-H1 on murine leukemia cells
was reported to mediate resistance to cytolytic T-cell destruction. We here investigate the
expression and function of the B7 homolog B7-H1 in human leukemia. PATIENTS AND
METHODS: Leukemia cells from 30 patients and 9 human leukemia cell lines were
investigated for B7-H1 expression by flow cytometry. Functional relevance of B7-H1 for …