An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
G Eberl, S Marmon, MJ Sunshine, PD Rennert… - Nature …, 2004 - nature.com
Nature immunology, 2004•nature.com
Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes
and Peyer's patches. We show here that during fetal life the nuclear hormone receptor
RORγt is expressed exclusively in and is required for the generation of LTi cells. RORγt+ LTi
cells provide essential factors, among which lymphotoxin-α1β2 is necessary but not
sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This
early LTi cell–mediated activation of lymph node and Peyer's patch mesenchyma forms the …
and Peyer's patches. We show here that during fetal life the nuclear hormone receptor
RORγt is expressed exclusively in and is required for the generation of LTi cells. RORγt+ LTi
cells provide essential factors, among which lymphotoxin-α1β2 is necessary but not
sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This
early LTi cell–mediated activation of lymph node and Peyer's patch mesenchyma forms the …
Abstract
Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORγt is expressed exclusively in and is required for the generation of LTi cells. RORγt+ LTi cells provide essential factors, among which lymphotoxin-α1β2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell–mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
nature.com