[HTML][HTML] Dual Retinoblastoma-binding Proteins with Properties Related to a Negative Regulator of Ras in Yeast (∗)
YW Qian, YHPL Eva - Journal of biological chemistry, 1995 - ASBMB
The retinoblastoma protein (Rb) interacts with multiple cellular proteins that mediate its
cellular function. We have identified nine polypeptides that bind to the T-binding domains of
Rb using an Rb affinity resin. RbAp48 and RbAp46 are quantitatively the major Rb-
associated proteins purified by this approach. RbAp48 was characterized previously and
was found to be related to MSI1, a negative regulator of Ras in the yeast Saccharomyces
cerevisiae. Here we report the cloning and characterization of RbAp46. RbAp46 shares …
cellular function. We have identified nine polypeptides that bind to the T-binding domains of
Rb using an Rb affinity resin. RbAp48 and RbAp46 are quantitatively the major Rb-
associated proteins purified by this approach. RbAp48 was characterized previously and
was found to be related to MSI1, a negative regulator of Ras in the yeast Saccharomyces
cerevisiae. Here we report the cloning and characterization of RbAp46. RbAp46 shares …