[HTML][HTML] Ras signaling enhances the activity of C/EBPα to induce granulocytic differentiation by phosphorylation of serine 248
G Behre, SM Singh, H Liu, LT Bortolin… - Journal of Biological …, 2002 - ASBMB
The transcription factor C/EBPα regulates early steps of normal granulocyte differentiation
since mice with a disruption of the C/EBPα gene do not express detectable levels of the
granulocyte colony-stimulating factor receptor and produce no neutrophils. We have recently
shown that C/EBPα function is also impaired in acute myeloid leukemias. However, how the
transcriptional activity of C/EBPα is regulated both in myelopoiesis and leukemogenesis is
not fully understood. The current study demonstrates that activated Ras enhances the ability …
since mice with a disruption of the C/EBPα gene do not express detectable levels of the
granulocyte colony-stimulating factor receptor and produce no neutrophils. We have recently
shown that C/EBPα function is also impaired in acute myeloid leukemias. However, how the
transcriptional activity of C/EBPα is regulated both in myelopoiesis and leukemogenesis is
not fully understood. The current study demonstrates that activated Ras enhances the ability …