[HTML][HTML] The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibitory effect of IL-1β on long term potentiation: a role for JNK
A Kelly, A Lynch, E Vereker, Y Nolan… - Journal of Biological …, 2001 - ASBMB
Several effects of the proinflammatory cytokine, interleukin-1β (IL-1β), have been described
in the central nervous system, and one area of the brain where marked changes have been
reported is the hippocampus. Among these changes are an IL-1β-induced inhibition of long
term potentiation (LTP) in perforant path-granule cell synapses and an attenuation of
glutamate release in synaptosomes prepared from the hippocampus. Evidence suggests
that, at least in circulating cells, the anti-inflammatory cytokine, IL-10, antagonizes certain …
in the central nervous system, and one area of the brain where marked changes have been
reported is the hippocampus. Among these changes are an IL-1β-induced inhibition of long
term potentiation (LTP) in perforant path-granule cell synapses and an attenuation of
glutamate release in synaptosomes prepared from the hippocampus. Evidence suggests
that, at least in circulating cells, the anti-inflammatory cytokine, IL-10, antagonizes certain …