The interleukins-1α,-1β, and-2 do not acutely disrupt the murine blood-brain barrier
WA Banks, AJ Kastin - International journal of immunopharmacology, 1992 - Elsevier
Previous studies have suggested that some of the central nervous system (CNS) effects of
interleukin-2 (IL-2) and perhaps other cytokines might be mediated through disruption of the
blood-brain barrier (BBB). We investigated the ability of human IL-2 and, in selected studies,
human IL-1α and human IL1β to disrupt the BBB to radioiodinated bovine serum albumin
(RISA) after intravenous (iv) and intracerebroventricular (icv) injection. No disruption of the
BBB occurred for up to 2 h after the iv injection of 2 μg/mouse of IL-2 (10 5 U/kg of body …
interleukin-2 (IL-2) and perhaps other cytokines might be mediated through disruption of the
blood-brain barrier (BBB). We investigated the ability of human IL-2 and, in selected studies,
human IL-1α and human IL1β to disrupt the BBB to radioiodinated bovine serum albumin
(RISA) after intravenous (iv) and intracerebroventricular (icv) injection. No disruption of the
BBB occurred for up to 2 h after the iv injection of 2 μg/mouse of IL-2 (10 5 U/kg of body …