[HTML][HTML] The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E
CC Bailey, LB DeVaux, M Farzan - Journal of Biological Chemistry, 2015 - ASBMB
The triggering receptor expressed on myeloid cells 2 (TREM2) is an Ig-like V-type receptor
expressed by populations of myeloid cells in the central nervous system and periphery. Loss-
of-function mutations in TREM2 cause a progressive, fatal neurodegenerative disorder
called Nasu-Hakola disease. In addition, a TREM2 R47H coding variant was recently
identified as a risk factor for late-onset Alzheimer disease. TREM2 binds various polyanionic
molecules but no specific protein ligands have been identified. Here we show that TREM2 …
expressed by populations of myeloid cells in the central nervous system and periphery. Loss-
of-function mutations in TREM2 cause a progressive, fatal neurodegenerative disorder
called Nasu-Hakola disease. In addition, a TREM2 R47H coding variant was recently
identified as a risk factor for late-onset Alzheimer disease. TREM2 binds various polyanionic
molecules but no specific protein ligands have been identified. Here we show that TREM2 …