[HTML][HTML] A mitotic cascade of NIMA family kinases: Nercc1/Nek9 activates the Nek6 and Nek7 kinases
The Nek family of protein kinases in humans is composed of 11 members that share an
amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the
control of several aspects of mitosis, and divergent carboxyl-terminal tails of varying length.
Nek6 (314AA) and Nek7 (303AA), 76% identical, have little noncatalytic sequence but bind
to the carboxyl-terminal noncatalytic tail of Nercc1/Nek9, a NIMA family protein kinase that is
activated in mitosis. Microinjection of anti-Nercc1 antibodies leads to spindle abnormalities …
amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the
control of several aspects of mitosis, and divergent carboxyl-terminal tails of varying length.
Nek6 (314AA) and Nek7 (303AA), 76% identical, have little noncatalytic sequence but bind
to the carboxyl-terminal noncatalytic tail of Nercc1/Nek9, a NIMA family protein kinase that is
activated in mitosis. Microinjection of anti-Nercc1 antibodies leads to spindle abnormalities …