Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis
J Sherr, E Tsalikian, L Fox, B Buckingham… - Diabetes …, 2014 - Am Diabetes Assoc
J Sherr, E Tsalikian, L Fox, B Buckingham, S Weinzimer, WV Tamborlane, NH White…
Diabetes care, 2014•Am Diabetes AssocOBJECTIVE To examine the evolution of the dysregulated glucagon responses to mixed-
meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH
DESIGN AND METHODS MMTTs were performed in 25 youth (9–18 years of age) with 1.5–
12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2).
Twenty nondiabetic (ND) control children were also studied. RESULTS In T1D children,
MMTT-stimulated increases in glucagon were significantly greater than that in ND children …
meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH
DESIGN AND METHODS MMTTs were performed in 25 youth (9–18 years of age) with 1.5–
12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2).
Twenty nondiabetic (ND) control children were also studied. RESULTS In T1D children,
MMTT-stimulated increases in glucagon were significantly greater than that in ND children …
OBJECTIVE
To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D).
RESEARCH DESIGN AND METHODS
MMTTs were performed in 25 youth (9–18 years of age) with 1.5–12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied.
RESULTS
In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16–30]; year 2, 25 pg/mL [16–30]; ND, 9 pg/mL [5–16]; P = 0.001 and P < 0.001, respectively).
CONCLUSIONS
In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted.
Am Diabetes Assoc