[PDF][PDF] Clonal history and genetic predictors of transformation into small-cell carcinomas from lung adenocarcinomas
Journal of clinical oncology, 2017•bktimes.net
Purpose Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-
cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the
molecular pathogenesis is still unclear.
cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the
molecular pathogenesis is still unclear.
Purpose
Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the molecular pathogenesis is still unclear.
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