Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings
JG Quinlan, HS Hahn, BL Wong, JN Lorenz… - Neuromuscular …, 2004 - Elsevier
Heart failure is a major cause of death in boys with Duchenne muscular dystrophy. In order
to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed
murine echocardiograms and left heart catheterization studies, along with morphometric
analysis of cardiac fibrosis. Serial echocardiograms in mdx mice revealed the evolution from
normal cardiac function in young mice to a dilated cardiomyopathy in adult mice. Very old
mdx mice exhibited a widespread but patchy increase in ventricular wall fibrosis. These …
to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed
murine echocardiograms and left heart catheterization studies, along with morphometric
analysis of cardiac fibrosis. Serial echocardiograms in mdx mice revealed the evolution from
normal cardiac function in young mice to a dilated cardiomyopathy in adult mice. Very old
mdx mice exhibited a widespread but patchy increase in ventricular wall fibrosis. These …