Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes
M Fanchaouy, E Polakova, C Jung, J Ogrodnik… - Cell calcium, 2009 - Elsevier
In Duchenne muscular dystrophy, deficiency of the cytoskeletal protein dystrophin leads to
well-described defects in skeletal muscle, but also to dilated cardiomyopathy, accounting for
about 20% of the mortality. Mechanisms leading to cardiomyocyte cell death and
cardiomyopathy are not well understood. One hypothesis suggests that the lack of
dystrophin leads to membrane instability during mechanical stress and to activation of Ca2+
entry pathways. Using cardiomyocytes isolated from dystrophic mdx mice we dissected the …
well-described defects in skeletal muscle, but also to dilated cardiomyopathy, accounting for
about 20% of the mortality. Mechanisms leading to cardiomyocyte cell death and
cardiomyopathy are not well understood. One hypothesis suggests that the lack of
dystrophin leads to membrane instability during mechanical stress and to activation of Ca2+
entry pathways. Using cardiomyocytes isolated from dystrophic mdx mice we dissected the …