Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells
E De Vuyst, N Wang, E Decrock, M De Bock, M Vinken… - Cell calcium, 2009 - Elsevier
Connexin hemichannels have a low open probability under normal conditions but open in
response to various stimuli, forming a release pathway for small paracrine messengers. We
investigated hemichannel-mediated ATP responses triggered by changes of intracellular
Ca2+ ([Ca2+] i) in Cx43 expressing glioma cells and primary glial cells. The involvement of
hemichannels was confirmed with gja1 gene-silencing and exclusion of other release
mechanisms. Hemichannel responses were triggered when [Ca2+] i was in the 500nM …
response to various stimuli, forming a release pathway for small paracrine messengers. We
investigated hemichannel-mediated ATP responses triggered by changes of intracellular
Ca2+ ([Ca2+] i) in Cx43 expressing glioma cells and primary glial cells. The involvement of
hemichannels was confirmed with gja1 gene-silencing and exclusion of other release
mechanisms. Hemichannel responses were triggered when [Ca2+] i was in the 500nM …