[HTML][HTML] CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
SH Cho, B Sun, Y Zhou, TM Kauppinen… - Journal of Biological …, 2011 - ASBMB
Aberrant microglial activation has been proposed to contribute to the cognitive decline in
Alzheimer disease (AD), but the underlying molecular mechanisms remain enigmatic.
Fractalkine signaling, a pathway mediating the communication between microglia and
neurons, is deficient in AD brains and down-regulated by amyloid-β. Although fractalkine
receptor (CX3CR1) on microglia was found to regulate plaque load, no functional effects
have been reported. Our study demonstrates that CX3CR1 deficiency worsens the AD …
Alzheimer disease (AD), but the underlying molecular mechanisms remain enigmatic.
Fractalkine signaling, a pathway mediating the communication between microglia and
neurons, is deficient in AD brains and down-regulated by amyloid-β. Although fractalkine
receptor (CX3CR1) on microglia was found to regulate plaque load, no functional effects
have been reported. Our study demonstrates that CX3CR1 deficiency worsens the AD …