Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth
RS Newfield - Medical hypotheses, 2015 - Elsevier
It is hypothesized that a topical application of a sulfonylurea drug, which can inhibit the ATP-
sensitive potassium-gated channels (Kir6. X/SUR) present in human hair bulb tissues, will
inhibit hair growth in a targeted manner. Diazoxide is used to treat severe hypoglycemia due
to hyperinsulinism of infancy. However, this often results in hypertrichosis that can be severe
enough to prevent its use. Diazoxide blocks insulin release from the pancreas by opening
the SUR1/Kir6. 2 channels in ß-cells. Diazoxide can also act on two potassium-gated …
sensitive potassium-gated channels (Kir6. X/SUR) present in human hair bulb tissues, will
inhibit hair growth in a targeted manner. Diazoxide is used to treat severe hypoglycemia due
to hyperinsulinism of infancy. However, this often results in hypertrichosis that can be severe
enough to prevent its use. Diazoxide blocks insulin release from the pancreas by opening
the SUR1/Kir6. 2 channels in ß-cells. Diazoxide can also act on two potassium-gated …