Several mechanisms contributing to the etiology of sarcopenia (age-related loss of muscle
size) have been postulated. One of these attributes the loss of muscle mass to a preceding
age-related denervation of myofibers. The aim of this study was to determine if signs of
denervation were apparent at the neuromuscular junction (NMJ) before fiber atrophy, or fiber
type conversion could be documented, and to reveal if a muscle's activity level impacts its
sensitivity to age-related denervation. Plantaris and soleus muscles were obtained from …