[HTML][HTML] Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans
A Vedala, W Wang, RA Neese, MP Christiansen… - Journal of lipid …, 2006 - ASBMB
Newly synthesized triglyceride (TG) may exit the liver immediately as VLDL-TG or be stored
and secreted after a delay. We quantified the contributions from plasma NEFA, diet, and de
novo lipogenesis (DNL) to VLDL-TG via immediate and delayed pathways in five lean,
normolipidemic subjects; six obese, hypertriglyceridemic (HPTG) nondiabetics; and six
obese, HPTG diabetics. Intravenous [2 H 31] palmitate and [1-13 C 1] acetate and oral [2 H
35] stearate were administered for 30 h preceding an overnight fast.[1, 2, 3, 4-13 C 4] …
and secreted after a delay. We quantified the contributions from plasma NEFA, diet, and de
novo lipogenesis (DNL) to VLDL-TG via immediate and delayed pathways in five lean,
normolipidemic subjects; six obese, hypertriglyceridemic (HPTG) nondiabetics; and six
obese, HPTG diabetics. Intravenous [2 H 31] palmitate and [1-13 C 1] acetate and oral [2 H
35] stearate were administered for 30 h preceding an overnight fast.[1, 2, 3, 4-13 C 4] …