[HTML][HTML] p27 protein protects metabolically stressed cardiomyocytes from apoptosis by promoting autophagy
p27 Kip1 (p27), a key regulator of cell division, has been implicated in autophagy of cancer
cells. However, its role in autophagy, the evolutionarily conserved catabolic process that
enables cells to remove unwanted proteins and damaged organelles, had not been
examined in the heart. Here we report that ectopic delivery of a p27 fusion protein (TAT-p27)
was sufficient to induce autophagy in neonatal rat ventricular cardiomyocytes in vitro, under
basal conditions and after glucose deprivation. Conversely, lentivirus-delivered shRNA …
cells. However, its role in autophagy, the evolutionarily conserved catabolic process that
enables cells to remove unwanted proteins and damaged organelles, had not been
examined in the heart. Here we report that ectopic delivery of a p27 fusion protein (TAT-p27)
was sufficient to induce autophagy in neonatal rat ventricular cardiomyocytes in vitro, under
basal conditions and after glucose deprivation. Conversely, lentivirus-delivered shRNA …