[HTML][HTML] Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells
JP Flacke, H Flacke, A Appukuttan, RJ Palisaar… - Journal of Biological …, 2013 - ASBMB
cAMP signaling plays an essential role in modulating the proliferation of different cell types,
including cancer cells. Until now, the regulation of this pathway was restricted to the
transmembrane class of adenylyl cyclases. In this study, significant overexpression of
soluble adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate
carcinoma, and therefore, the contribution of this cyclase was investigated in the prostate
carcinoma cell lines LNCaP and PC3. Suppression of sAC activity by treatment with the sAC …
including cancer cells. Until now, the regulation of this pathway was restricted to the
transmembrane class of adenylyl cyclases. In this study, significant overexpression of
soluble adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate
carcinoma, and therefore, the contribution of this cyclase was investigated in the prostate
carcinoma cell lines LNCaP and PC3. Suppression of sAC activity by treatment with the sAC …