Abstract Sporadic Creutzfeldt–Jakob disease (CJD), the most common human prion
disease, is generally regarded as a spontaneous neurodegenerative illness, arising either
from a spontaneous PRNP somatic mutation or a stochastic PrP structural change.
Alternatively, the possibility of an infection from animals or other source remains to be
completely ruled out. Sporadic CJD is clinically characterized by rapidly progressive
dementia with ataxia, myoclonus, or other neurologic signs and, neuropathologically, by the …