Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression
M Elsayed, M Banasr, V Duric, NM Fournier… - Biological …, 2012 - Elsevier
BACKGROUND: Basic and clinical studies report that the expression of fibroblast growth
factor-2 (FGF-2) is decreased in the prefrontal cortex (PFC) of depressed subjects or rodents
exposed to stress and increased following antidepressant treatment. Here, we aim to
determine if 1) FGF-2/fibroblast growth factor receptor (FGFR) signaling is sufficient and
required for mediating an antidepressant response behaviorally and cellularly; and 2) if the
antidepressant actions of FGF-2 are mediated specifically by the PFC. METHODS: The role …
factor-2 (FGF-2) is decreased in the prefrontal cortex (PFC) of depressed subjects or rodents
exposed to stress and increased following antidepressant treatment. Here, we aim to
determine if 1) FGF-2/fibroblast growth factor receptor (FGFR) signaling is sufficient and
required for mediating an antidepressant response behaviorally and cellularly; and 2) if the
antidepressant actions of FGF-2 are mediated specifically by the PFC. METHODS: The role …