The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents

O Malkesman, ML Scattoni, D Paredes, T Tragon… - Biological …, 2010 - Elsevier
BACKGROUND: Abnormal hedonic behavior is a key feature of many psychiatric disorders.
Several paradigms measure reward-seeking behavior in rodents, but each has limitations.
We describe a novel approach for monitoring reward-seeking behavior in rodents: sniffing of
estrus female urine by male mice, along with number of ultrasonic vocalizations (USVs)
emitted during the test. METHODS: The female urine sniffing test (FUST) was designed to
monitor reward-seeking activity in rodents together with tests of helplessness and sweet …