Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice
CM Gillis, F Jönsson, DA Mancardi, N Tu… - Journal of Allergy and …, 2017 - Elsevier
Background Anaphylaxis can proceed through distinct IgE-or IgG-dependent pathways,
which have been investigated in various mouse models. We developed a novel mouse
strain in which the human low-affinity IgG receptor locus, comprising both activating
(hFcγRIIA, hFcγRIIIA, and hFcγRIIIB) and inhibitory (hFcγRIIB) hFcγR genes, has been
inserted into the equivalent murine locus, corresponding to a locus swap. Objective We
sought to determine the capabilities of hFcγRs to induce systemic anaphylaxis and identify …
which have been investigated in various mouse models. We developed a novel mouse
strain in which the human low-affinity IgG receptor locus, comprising both activating
(hFcγRIIA, hFcγRIIIA, and hFcγRIIIB) and inhibitory (hFcγRIIB) hFcγR genes, has been
inserted into the equivalent murine locus, corresponding to a locus swap. Objective We
sought to determine the capabilities of hFcγRs to induce systemic anaphylaxis and identify …