Inflammatory mediators of endothelial injury in sickle cell disease
CC Hoppe - Hematology/Oncology Clinics, 2014 - hemonc.theclinics.com
SCD is now recognized as a complex disease characterized by acute and chronic
inflammation. The incidence of nearly every clinical manifestation of SCD correlates with
white blood cell (WBC) count, indicating a role for leukocytes and inflammation in the
pathophysiology of SCD. Leukocytosis is common in SCD patients and is manifested by
elevation in monocyte and neutrophil counts, 1–3 accompanied by elevated levels of
circulating inflammatory cytokines, including tumor necrosis factor a (TNF-a), interleukin (IL) …
inflammation. The incidence of nearly every clinical manifestation of SCD correlates with
white blood cell (WBC) count, indicating a role for leukocytes and inflammation in the
pathophysiology of SCD. Leukocytosis is common in SCD patients and is manifested by
elevation in monocyte and neutrophil counts, 1–3 accompanied by elevated levels of
circulating inflammatory cytokines, including tumor necrosis factor a (TNF-a), interleukin (IL) …