[HTML][HTML] Endothelial-dependent vasodilation is impaired in children with sickle cell disease
M de Montalembert, Y Aggoun, A Niakate… - …, 2007 - haematologica.org
M de Montalembert, Y Aggoun, A Niakate, I Szezepanski, D Bonnet
Haematologica, 2007•haematologica.orgImpairment of endothelial-dependent vasodilation has been demonstrated in adults with
sickle cell anemia (SCA). We enrolled 21 SCA children, mean age 10.4±3.3 yrs, and 23 Afro-
Caribbean controls. We examined flow-mediated (FMD) and nitroglycerine-mediated
(GTNMD) dilation of the brachial artery, using echotracking techniques, and measured
intima-media thickness (IMT) and mechanical properties of the common carotid artery. FMD
was significantly decreased in SCA children vs controls (5.6±0.2 vs 8.0±0.2%, p= 0.008) …
sickle cell anemia (SCA). We enrolled 21 SCA children, mean age 10.4±3.3 yrs, and 23 Afro-
Caribbean controls. We examined flow-mediated (FMD) and nitroglycerine-mediated
(GTNMD) dilation of the brachial artery, using echotracking techniques, and measured
intima-media thickness (IMT) and mechanical properties of the common carotid artery. FMD
was significantly decreased in SCA children vs controls (5.6±0.2 vs 8.0±0.2%, p= 0.008) …
Abstract
Impairment of endothelial-dependent vasodilation has been demonstrated in adults with sickle cell anemia (SCA). We enrolled 21 SCA children, mean age 10.4±3.3 yrs, and 23 Afro-Caribbean controls. We examined flow-mediated (FMD) and nitroglycerine-mediated (GTNMD) dilation of the brachial artery, using echotracking techniques, and measured intima-media thickness (IMT) and mechanical properties of the common carotid artery. FMD was significantly decreased in SCA children vs controls (5.6±0.2 vs 8.0±0.2%, p= 0.008), while IMT, stiffness of the common carotid artery, and GTNMD were comparable. In conclusion, endothelial dysfunction is present as early as childhood in SCA patients.
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