Cachexia and sarcopenia: mechanisms and potential targets for intervention

JM Argiles, S Busquets, B Stemmler… - Current opinion in …, 2015 - Elsevier
Highlights•Cachexia and sarcopenia share common trends: altered protein synthesis and
degradation.•Cachexia and sarcopenia are both driven by inflammation.•Sarcopenia is
ameliorated by resistance training, ingestion of AA, and testosterone.•Cachexia is
ameliorated by progestagens, corticosteroids, ghrelin agonists, myostatin antagonists and
SARMs.Cachexia is a multi-organ syndrome associated with cancer and other chronic
diseases, characterized by body weight loss, muscle and adipose tissue wasting and …