[HTML][HTML] Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion
α-Tubulin acetylation at Lys-40, located on the luminal side of microtubules, has been widely
studied and used as a marker for stable microtubules in the cilia and other subcellular
structures, but the functional consequences remain perplexing. Recent studies have shown
that Mec-17 and its paralog are responsible for α-tubulin acetylation in Caenorhabditis
elegans. There is one such protein known as Atat1 (α-tubulin acetyltransferase 1) per higher
organism. Zebrafish Atat1 appears to govern embryo development, raising the intriguing …
studied and used as a marker for stable microtubules in the cilia and other subcellular
structures, but the functional consequences remain perplexing. Recent studies have shown
that Mec-17 and its paralog are responsible for α-tubulin acetylation in Caenorhabditis
elegans. There is one such protein known as Atat1 (α-tubulin acetyltransferase 1) per higher
organism. Zebrafish Atat1 appears to govern embryo development, raising the intriguing …