[HTML][HTML] LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses
F Tokunaga, K Iwai - Microbes and infection, 2012 - Elsevier
LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of
SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the
NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on
the regulation of NF-κB by LUBAC and the diseases associated with this process are the
focus of this review.
SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the
NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on
the regulation of NF-κB by LUBAC and the diseases associated with this process are the
focus of this review.