Efficiencies of platform clinical trials: a vision of the future
BR Saville, SM Berry - Clinical Trials, 2016 - journals.sagepub.com
BR Saville, SM Berry
Clinical Trials, 2016•journals.sagepub.comBackground: A “platform trial” is a clinical trial with a single master protocol in which multiple
treatments are evaluated simultaneously. Adaptive platform designs offer flexible features
such as dropping treatments for futility, declaring one or more treatments superior, or adding
new treatments to be tested during the course of a trial. Methods: A simulation study
explores the efficiencies of various platform trial designs relative to a traditional two-arm
strategy. Results: Platform trials can find beneficial treatments with fewer patients, fewer …
treatments are evaluated simultaneously. Adaptive platform designs offer flexible features
such as dropping treatments for futility, declaring one or more treatments superior, or adding
new treatments to be tested during the course of a trial. Methods: A simulation study
explores the efficiencies of various platform trial designs relative to a traditional two-arm
strategy. Results: Platform trials can find beneficial treatments with fewer patients, fewer …
Background
A “platform trial” is a clinical trial with a single master protocol in which multiple treatments are evaluated simultaneously. Adaptive platform designs offer flexible features such as dropping treatments for futility, declaring one or more treatments superior, or adding new treatments to be tested during the course of a trial.
Methods
A simulation study explores the efficiencies of various platform trial designs relative to a traditional two-arm strategy.
Results
Platform trials can find beneficial treatments with fewer patients, fewer patient failures, less time, and with greater probability of success than a traditional two-arm strategy.
Conclusion
In an era of personalized medicine, platform trials provide the innovation needed to efficiently evaluate modern treatments.
Sage Journals