CD4+ CXCR5+ T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses
M Spaan, K Kreefft, GN de Graav, WP Brouwer… - Journal of …, 2015 - Elsevier
Background & Aims During chronic HCV infection, T cell dependent virus-specific antibodies
are produced. However, the role of BT cell interaction in chronic HCV is largely unknown.
CD4+ CXCR5+ T follicular helper (T FH)-cells activate B cells and are important for
clearance of various chronic viral infections. We investigated the function of T FH cells and B
cells in liver and in peripheral blood of chronic HCV patients. Methods T cells from chronic
HCV patients and healthy individuals were analysed for expression of CXCR5, PD-1, ICOS …
are produced. However, the role of BT cell interaction in chronic HCV is largely unknown.
CD4+ CXCR5+ T follicular helper (T FH)-cells activate B cells and are important for
clearance of various chronic viral infections. We investigated the function of T FH cells and B
cells in liver and in peripheral blood of chronic HCV patients. Methods T cells from chronic
HCV patients and healthy individuals were analysed for expression of CXCR5, PD-1, ICOS …