[HTML][HTML] From non-A, non-B hepatitis to hepatitis C virus cure
JM Pawlotsky, JJ Feld, S Zeuzem, JH Hoofnagle - Journal of hepatology, 2015 - Elsevier
The hepatitis C virus (HCV) was discovered in the late 1980s. Interferon (IFN)-α was
proposed as an antiviral treatment for chronic hepatitis C at about the same time. Successive
improvements in IFN-α-based therapy (dose finding, pegylation, addition of ribavirin)
increased the rates of sustained virologic response, ie the rates of curing HCV infection.
These rates were further improved by adding the first available direct-acting antiviral (DAA)
drugs to the combination of pegylated IFN-α and ribavirin. An IFN-free era finally started in …
proposed as an antiviral treatment for chronic hepatitis C at about the same time. Successive
improvements in IFN-α-based therapy (dose finding, pegylation, addition of ribavirin)
increased the rates of sustained virologic response, ie the rates of curing HCV infection.
These rates were further improved by adding the first available direct-acting antiviral (DAA)
drugs to the combination of pegylated IFN-α and ribavirin. An IFN-free era finally started in …