Stress erythropoiesis: new signals and new stress progenitor cells
The BMP4-dependent stress erythropoiesis pathway plays a key role in the recovery from
acute anemia and new data show that this pathway compensates for ineffective steady state
erythropoiesis in a murine model of chronic anemia. The identification of a self-renewing
population of stress erythroid progenitors in mice suggests that therapeutic manipulation of
this pathway may be useful for the treatment of human anemia. However, the development
of new therapies will await the characterization of an analogous pathway in humans.
acute anemia and new data show that this pathway compensates for ineffective steady state
erythropoiesis in a murine model of chronic anemia. The identification of a self-renewing
population of stress erythroid progenitors in mice suggests that therapeutic manipulation of
this pathway may be useful for the treatment of human anemia. However, the development
of new therapies will await the characterization of an analogous pathway in humans.
Summary
The BMP4-dependent stress erythropoiesis pathway plays a key role in the recovery from acute anemia and new data show that this pathway compensates for ineffective steady state erythropoiesis in a murine model of chronic anemia. The identification of a self-renewing population of stress erythroid progenitors in mice suggests that therapeutic manipulation of this pathway may be useful for the treatment of human anemia. However, the development of new therapies will await the characterization of an analogous pathway in humans.
Lippincott Williams & Wilkins