Downregulation of MEIS1 impairs long-term expansion of CD34+ NPM1-mutated acute myeloid leukemia cells

CM Woolthuis, L Han, RN Verkaik-Schakel… - Leukemia, 2012 - nature.com
CM Woolthuis, L Han, RN Verkaik-Schakel, D van Gosliga, PM Kluin, E Vellenga…
Leukemia, 2012nature.com
1 Li HY, Appelbaum FR, Willman CL, Zager RA, Banker DE. Cholesterol-modulating agents
kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive
cholesterol responses. Blood 2003; 101: 3628–3634. 2 Vitols S, Norgren S, Juliusson G,
Tatidis L, Luthman H. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-
3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells.
Blood 1994; 84: 2689–2698. 3 Banker DE, Mayer SJ, Li HY, Willman CL, Appelbaum FR …
1 Li HY, Appelbaum FR, Willman CL, Zager RA, Banker DE. Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. Blood 2003; 101: 3628–3634. 2 Vitols S, Norgren S, Juliusson G, Tatidis L, Luthman H. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood 1994; 84: 2689–2698. 3 Banker DE, Mayer SJ, Li HY, Willman CL, Appelbaum FR, Zager RA. Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. Blood 2004; 104: 1816–1824.
4 van der Weide K, Jonge-Peeters SD, Kuipers F, de Vries EG, Vellenga E. Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. Clin Cancer Res 2009; 15: 3076–3083. 5 Dai Y, Khanna P, Chen S, Pei XY, Dent P, Grant S. Statins synergistically potentiate 7-hydroxystaurosporine
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