The CBM signalosome: potential therapeutic target for aggressive lymphoma?

C Yang, L David, Q Qiao, E Damko, H Wu - Cytokine & growth factor …, 2014 - Elsevier
The CBM signalosome plays a pivotal role in mediating antigen-receptor induced NF-κB
signaling to regulate lymphocyte functions. The CBM complex forms filamentous structure
and recruits downstream signaling components to activate NF-κB. MALT1, the protease
component in the CBM complex, cleaves key proteins in the feedback loop of the NF-κB
signaling pathway and enhances NF-κB activation. The aberrant activity of the CBM complex
has been linked to aggressive lymphoma. Recent years have witnessed dramatic …