Cellular proteolytic modification of tumor-suppressor CYLD is critical for the initiation of human T-cell acute lymphoblastic leukemia
There exists a general recognition of the fact that post translational modification of CYLD
protein through proteolytic cleavage by MALT-1 results in sustained cellular NF-kB activity
which is conspicuously found to be associated with cancer in general and hematological
malignancies in particular. The present study was directed to understand the contribution of
MALT-1 and deubiquitinase CYLD to the initiation of T-cell acute lymphoblastic leukemia (T-
ALL). Such a study revealed for the first time that the 35 kDa CYLD cleaved factor generated …
protein through proteolytic cleavage by MALT-1 results in sustained cellular NF-kB activity
which is conspicuously found to be associated with cancer in general and hematological
malignancies in particular. The present study was directed to understand the contribution of
MALT-1 and deubiquitinase CYLD to the initiation of T-cell acute lymphoblastic leukemia (T-
ALL). Such a study revealed for the first time that the 35 kDa CYLD cleaved factor generated …