Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma
J Chen, M Miller, H Unno, P Rosenthal… - Journal of Allergy and …, 2018 - Elsevier
Background Airway hyperresponsiveness is a major feature of asthma attributed
predominantly to an extrinsic immune/inflammatory response increasing airway smooth
muscle (ASM) contractility. Objective We investigated whether increased ASM expression of
orosomucoid-like 3 (ORMDL3), a gene on chromosome 17q21 highly linked to asthma,
induced increased ASM proliferation and contractility in vitro and influenced airway
contractility and calcium flux in ASM in precision-cut lung slices (PCLSs) from wild-type and …
predominantly to an extrinsic immune/inflammatory response increasing airway smooth
muscle (ASM) contractility. Objective We investigated whether increased ASM expression of
orosomucoid-like 3 (ORMDL3), a gene on chromosome 17q21 highly linked to asthma,
induced increased ASM proliferation and contractility in vitro and influenced airway
contractility and calcium flux in ASM in precision-cut lung slices (PCLSs) from wild-type and …