[HTML][HTML] Antibody blocks acquisition of bacterial colonization through agglutination

AM Roche, AL Richard, JT Rahkola, EN Janoff… - Mucosal …, 2015 - Elsevier
Invasive infection often begins with asymptomatic colonization of mucosal surfaces. A
murine model of bacterial colonization with Streptococcus pneumoniae was used to study
the mechanism for mucosal protection by immunoglobulin. In previously colonized immune
mice, bacteria were rapidly sequestered within large aggregates in the nasal lumen. To
further examine the role of bacterial agglutination in protection by specific antibodies, mice
were passively immunized with immunoglobulin G (IgG) purified from antipneumococcal …