Immune responses to pneumococcal pilus RrgA and RrgB antigens and their relationship with pneumococcal carriage in humans

MS Ahmed, S Derbyshire, B Flanagan, C Loh… - Journal of Infection, 2014 - Elsevier
Objectives Pneumococcal pilus antigens are shown to be important in pneumococcal
pathogenesis and induce protective immunity in animal studies, but data in humans are
limited. We aimed to investigate serum and mucosal immune responses to pilus-1 proteins
(RrgA and RrgB) and their relationship with pneumococcal carriage in humans. Methods
Serum and salivary antibodies to RrgA and RrgB in children and adults were analysed by
ELISA and immunoblotting. Induction of B cell antibody responses to RrgA and RrgB in …