Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis

Y Li, H Wang, Y Long, Z Lu, X Hu - Journal of neuroimmunology, 2011 - Elsevier
Object To investigate the clinical relevance of memory Th17 cells in patients with
neuromyelitis optica (NMO) or multiple sclerosis (MS). Patients and methods The proportion
of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23
levels were detected by ELISA kits. Results Memory Th17 proportion and IL-17A level were
much higher in patients with NMO or MS and were related to clinical features. After high-
dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A …