The neural crest in cardiac congenital anomalies

A Keyte, MR Hutson - Differentiation, 2012 - Elsevier
This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly
30 years ago by ablation of premigratory neural crest. The cardiac neural crest cells are
necessary for normal cardiovascular development. We begin with a description of the crest
cells in normal development, including their function in remodeling the pharyngeal arch
arteries, outflow tract septation, valvulogenesis, and development of the cardiac conduction …