Genetic network during neural crest induction: from cell specification to cell survival
Seminars in cell & developmental biology, 2005•Elsevier
The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate
a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In
this review we will analyze the extracellular signals and the network of transcription factors
that are required for this transformation. We will propose the division of this complex network
of factors in two main steps: an initial cell specification step followed by a maintenance or
cell survival step.
a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In
this review we will analyze the extracellular signals and the network of transcription factors
that are required for this transformation. We will propose the division of this complex network
of factors in two main steps: an initial cell specification step followed by a maintenance or
cell survival step.
The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.
Elsevier